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norskBlar i forfatter "Berg, Vivian"
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Assessing the relationship between perfluoroalkyl substances, thyroid hormones and binding proteins in pregnant women; a longitudinal mixed effects approach
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-04)<p>The mechanisms involved in thyroid homeostasis are complex, and perfluoroalkyl substances (PFASs) have been indicated to interfere at several levels in this endocrine system. Disruption of the maternal thyroid homeostasis during early pregnancy is of particular concern, where subclinical changes in maternal thyroid hormones (THs) may affect embryonic and foetal development.</p> <p>The present ... -
Cancer-associated fibroblasts from human NSCLC survive ablative doses of radiation but their invasive capacity is reduced
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)BACKGROUND: Cancer-Associated Fibroblasts (CAFs) are significant components of solid malignancies and play central roles in cancer sustainability, invasion and metastasis. In this study we have investigated the invasive capacity and matrix remodelling properties of human lung CAFs after exposure to ablative doses of ionizing radiation (AIR), equivalent to single fractions delivered by stereotactic ... -
Changes in the secretory profile of NSCLC-associated fibroblasts after ablative radiotherapy: Potential impact on angiogenesis and tumor growth
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014-03-05)In the context of radiotherapy, collateral effects of ablative ionizing radiation (AIR) on stromal components of tumors remains understudied. In this work, cancer-associated fibroblasts (CAFs) isolated from freshly resected human lung tumors were exposed to AIR (1x18Gy) and analyzed for their release of paracrine factors. Inflammatory mediators and regulators of angiogenesis and tumor growth were ... -
Concentrations and predictors of persistent organic pollutants in pregnant women and associations with maternal and infant thyroid homeostasis. The Northern Norway Mother-and-Child Contaminant Cohort Study
(Doctoral thesis; Doktorgradsavhandling, 2015-12-10)During the 20th century, humans have been exposed to an increasing number of persistent organic pollutants (POPs). However, due to restrictions on use and the banning of several POPs, environmental concentrations of POPs have generally decreased since the 1980s. POPs are transferred to humans primarily through diet and are transferred from the mother to the foetus during pregnancy and to infants ... -
Effects of Vitamin D binding protein phenotypes and Vitamin D supplementation on serum total 25(OH)D and directly measured free 25(OH)D
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-01-05)Objective:<br>To determine the relationship between serum total 25-hydroxyvitamin D (25(OH)D), directly measured free 25(OH)D and calculated free 25(OH)D with regard to vitamin D-binding protein (DBP) phenotypes, sex, BMI, age and season, and their interrelationship to vitamin D supplementation.<br>Design, patients and interventions:<br>A randomized controlled trial with 20 000 IU of vitamin D3 per ... -
Human articular chondrocytes express Chemerin receptor, ChemR23, which conveys inflammatory signalling
(Master thesis; Mastergradsoppgave, 2008-12-17)Common features of arthritis include destruction of extracellular matrices in cartilage and bone as a result of chronic inflammation. Cartilage deterioration is generally described as a result from the effect of immune cells and their inflammatory mediators. However, recent reports suggest a role of chondrocytes in the initiation of inflammation in joints, and that they play a pivotal role in the ... -
Human articular chondrocytes express ChemR23 and chemerin; ChemR23 promotes inflammatory signalling upon binding the ligand chemerin 21-157
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010)Chemerin is a chemotactic peptide which directs leukocytes expressing the chemokine-like receptor ChemR23 towards sites of inflammation. ChemR23 is a G protein-coupled receptor which binds several different ligands, and it is also expressed by other cell types such as adipocytes. In addition to chemotaxis, recent reports suggest that ChemR23 is capable of mediating either inflammatory or anti-inflammatory ... -
Legacy perfluoroalkyl acids and their oxidizable precursors in plasma samples of Norwegian women
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-12)Humans are exposed to perfluoroalkyl acids (PFAA) mainly through direct pathways, such as diet and drinking water, but indirect exposure also occurs when PFAA precursors break down to form legacy PFAA. Exposure to PFAA precursors raises particular concern, as neither the exposure nor the precursors themselves have been well described. In the present study, we aimed to assess the indirect contribution ... -
Longitudinal changes in blood biomarkers and their ability to predict type 2 diabetes mellitus—The Tromsø study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-11)Introduction: Identification of individuals at high risk of developing type 2 diabetes mellitus (T2DM) is important for early prevention of the disease. Once T2DM is established, it is difficult to treat and is associated with cardiovascular complications and increased mortality. We aimed to describe pre- and post-diagnostic changes in blood biomarker concentrations over 30 years in individuals ... -
Longitudinal changes in concentrations of persistent organic pollutants (1986–2016) and their associations with type 2 diabetes mellitus
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-28)Background: Positive associations have been reported between persistent organic pollutants (POPs) and type 2 diabetes mellitus (T2DM); however, causality has not been established. Over the last decades, environmental exposure to legacy POPs has decreased, complicating epidemiological studies. In addition, physiological risk factors for T2DM may also influence POP concentrations, contributing to ... -
Longitudinal changes in vitamin D concentrations and the association with type 2 diabetes mellitus: the Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-02)Aim We aimed to investigate the relationship between pre- and post-diagnostic 25-hydroxyvitamin D (25(OH)D) concentrations and type 2 diabetes (T2DM) over a period of 30 years in individuals who developed T2DM compared to healthy controls.<p> <p>Methods This case–control study included 254 participants with blood samples collected at fve diferent time-points (T1–T5) between 1986 and 2016. Of the ... -
Maternal serum concentrations of per- and polyfluoroalkyl substances and their predictors in years with reduced production and use
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
Persistent Organic Pollutants and the Association with Maternal and Infant Thyroid Homeostasis: A Multipollutant Assessment
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-01)Background:<br>Disruption of thyroid homeostasis has been indicated in human studies targeting effects of persistent organic pollutants (POPs). Influence on the maternal thyroid system by POPs is of special interest during pregnancy because such effects could impair infant thyroid homeostasis.<br> Objectives:<br>We investigated the association between POPs and thyroid-stimulating hormone (TSH) ... -
Polybrominated diphenyl ethers in type 2 diabetes mellitus cases and controls: Repeated measurements prior to and after diagnosis
(Journal article; Tidsskriftartikkel, 2023-03-05)<p><i>Background:</i> Previous studies have reported associations between certain persistent organic pollutants (POPs) and type 2 diabetes mellitus (T2DM). Polybrominated diphenyl ethers (PBDEs) are a class of POPs that are found in increasing concentrations in humans. Although obesity is a known risk factor for T2DM and PBDEs are fat-soluble, very few studies have investigated associations between ... -
Praksisstudienes omfang og organisering i bioingeniørutdanningen
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022)Siden 2005 har omfang og innhold i bioingeniørutdanningen vært definert av en nasjonal rammeplan for å sikre likeverdig sluttkompetanse for alle kandidater. Fra 2019 ble en ny forskrift om nasjonale retningslinjer fastsatt. Både tidligere rammeplan og nye retningslinjer har regulert læringsutbyttene og omfang av praksis i utdanningen. I denne studien kartlegges omfang og organisering av praksisstudiene ... -
Pre- and post-diagnostic blood profiles of chlorinated persistent organic pollutants and metabolic markers in type 2 diabetes mellitus cases and controls; a pilot study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-09)Objective - Several risk factors for type 2 diabetes mellitus (T2DM) are also associated with blood concentrations of persistent organic pollutants (POPs), and factors related to the disease may affect POP concentrations, and subsequent associations between POPs and T2DM. The purpose of this pilot study was to investigate the change in concentrations of lipids, hormones and POPs pre- and post-diagnosis ... -
Pre- and post-diagnostic blood profiles of perfluoroalkyl acids in type 2 diabetes mellitus cases and controls
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-09)<i>Background</i> - Studies exploring the associations between perfluoroalkyl acids (PFAAs) and type 2 diabetes mellitus (T2DM) are rather limited and have reported conflicting results. All studies to date, including prospective ones, have relied on a single blood sample to study this association. Similarly, studies investigating how T2DM status may influence the longitudinal changes in PFAA ... -
Predicting human plasma concentrations of persistent organic pollutants from dietary intake and socio-demographic information in the Norwegian Women and Cancer study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-09)<i>Background</i> - Concentrations of persistent organic pollutants (POPs) in humans are influenced by a large number of factors including birth year, reproductive history and diet. Accordingly, information on dietary habits and socio-demographic variables may predict plasma concentrations of POPs, thus enabling studies on health effects in large epidemiological studies, without performing time ... -
Repeated measurements of per- and polyfluoroalkyl substances (PFASs) from 1979 to 2007 in males from Northern Norway: Assessing time trends, compound correlations and relations to age/birth cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014-06)<p><i>Background</i> Longitudinal biomonitoring studies can provide unique information on how human concentrations change over time, but have so far not been conducted for per- and polyfluoroalkyl substances (PFASs) in a background exposed population.</p> <p> <i>Objectives</i> The objectives of this study were to determine: i) serum PFAS time trends on an individual level; ii) relative ... -
Thyroid homeostasis in mother–child pairs in relation to maternal iodine status. The MISA study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-05-24)BACKGROUND/OBJECTIVES: Iodine deficiency during pregnancy may influence maternal and foetal thyroid function with the risk of causing neurocognitive and psychomotor deficits in the offspring. The objective of this study was to assess iodine status in pregnant women from Northern Norway and to investigate the influence of iodine status on maternal and infant thyroid function. <br>SUBJECTS/METHODS: ...
